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The picture above is of a single cell (photo credit Susanna Stroik); DNA is in blue, a marker for chromosome breaks in magenta. Defective repair of chromosome breaks led to catastrophic shattering of the genome and nucleus into micronuclei.

How does repair of chromosome breaks work, and what happens when it doesn’t? What does this mean for carcinogenesis and cancer therapy? Current interests:

1. Pol θ’s contribution to genome stability. More here.

2. Why use RNA to repair DNA? More here.

Chromosome breaks are repaired by Nonhomologous end joining (NHEJ), Theta mediated end joining (TMEJ), Single strand annealing (SSA), or Homologous recombination (HR)