Publications
++Senior Authorship; *Trainee within the Rager laboratory; #Data analyst within the Rager laboratory
2023
Vitucci E, Carberry CK*, Payton A#, Herring LE, Mordant AL, McCullough SD, Rager JE++. Characterizing the Extracellular Vesicle Proteomic Landscape of the Human Airway Using In Vitro Organotypic Multi-Cellular Models. Cell – iScience. 2023 Nov 17. doi: 10.1016/ j.isci.2023.108162. PMID: 37920665. PMCID: PMC10618692.
Carberry CK*, Bangma J, Koval L*, Keshava D, Hartwell HJ, Sokolsky M, Fry RC, Rager JE++. Extracellular Vesicles altered by a Per- and Polyfluoroalkyl Substance Mixture: In Vitro Dose-Dependent Release, Chemical Content, and MicroRNA Signatures involved in Liver Health. Toxicol Sci. 2023 Oct 18:kfad108. doi: 10.1093/toxsci/kfad108. Epub ahead of print. PMID: 37851381.
Eaves LA, Keil AP, Jukic AM, Dhingra R, Brooks JL, Manuck TA, Rager JE, Fry RC. Toxic metal mixtures in private well water and increased risk for preterm birth in North Carolina. Environ Health. 2023 Oct 16;22(1):69. doi: 10.1186/s12940-023-01021-7. PMID: 37845729. PMCID: PMC10577978.
Rager JE, Rider CV. Wrangling Whole Mixtures Risk Assessment: Recent Advances in Determining Sufficient Similarity. Curr Opin Toxicol. 2023 Sep;35:100417. doi: 10.1016/j.cotox.2023.100417. PMID: 37790747; PMCID: PMC10545370.
Payton A#, Roell KR, Rebuli ME, Valdar W, Jaspers I, Rager JE++. Navigating the bridge between wet and dry lab toxicology research to address current challenges with high-dimensional data. Front Toxicol. 2023 May 26;5. doi: 10.3389/ftox.2023.1171175.
Jin B, Dunson DB, Rager JE, Reif DM, Engel SM, Herring AH. Bayesian Matrix Completion for Hypothesis Testing. J R Stat Soc Ser C Appl Stat. 2023 Mar 15;72(2):254-270. doi: 10.1093/jrsssc/qlac005. PMID: 37197290; PMCID: PMC10184491.
Perryman A, Hye-Young H, Payton A#, Rager JE, McNell EE, Rebuli ME, Wells H, Almond M, Antinori J, Alexis NE, Porter NA, Jaspers I. Plasma sterols and vitamin D are correlates and predictors of ozone-induced inflammation in the lung: A pilot study. 2023. PLoS One. 2023 May 15;18(5):e0285721. doi: 10.1371/journal.pone.0285721. PMID: 37186612.
Freedman AN, Clark J, Eaves LA, Roell K, Oran A, Koval L*, Rager J, Santos HP Jr, Kuban K, Joseph RM, Frazier J, Marsit CJ, Burt AA, O’Shea TM, Fry RC. A multi-omic approach identifies an autism spectrum disorder (ASD) regulatory complex of functional epimutations in placentas from children born preterm. Autism Res. 2023 May;16(5):918-934. doi: 10.1002/aur.2915. Epub 2023 Mar 20. PMID: 36938998; PMCID: PMC10192070.
2022
Carberry CK*, Rager JE++. The Impact of Environmental Contaminants on Extracellular Vesicles and their Key Molecular Regulators: A Literature and Database-Driven Review. Environ Mol Mutagen. 2022 Dec 11. doi: 10.1002/em.22522. Epub ahead of print. PMID: 36502378.
Eaves LA, Bulka CM, Rager JE, Gardner AJ, Galusha AL, Parsons PJ, O’Shea TM, Fry RC. Metal mixtures modeling identifies birth weight-associated gene networks in the placentas of children born extremely preterm. Chemosphere. 2022 Dec 6:137469. doi: 10.1016/j.chemosphere.2022.137469. Epub ahead of print. PMID: 36493891.
Eaves LA, Lanier P, Enggasser AE, Chung G, Turla T*, Rager JE, Fry RC. Generation of the Chemical and Social Stressors Integration Technique (CASS-IT) to identify areas of holistic public health concern: An application to North Carolina. Sci Total Environ. 2022 Nov 24:160409. doi: 10.1016/j.scitotenv.2022.160409. Epub ahead of print. PMID: 36436630.
Koval LE*, Carberry CK*, Kim YH, McDermott E*, Hartwell H, Jaspers I, Gilmour MI, Rager JE++. Wildfire Variable Toxicity: Identifying Biomass Smoke Exposure Groupings through Transcriptomic Similarity Scoring. Environ Sci Technol. 2022 Nov 18. doi: 10.1021/acs.est.2c06043. Epub ahead of print. PMID: 36399130.
Kim YH, Rager JE, Jaspers I, Gilmour MI. Computational Approach to Link Chemicals in Anthropogenic Smoke Particulate Matter with Toxicity. Chem Res Toxicol. 2022 Nov 14. doi: 10.1021/acs.chemrestox.2c00270. Epub ahead of print. PMID: 36373932.
Wambaugh JF, Rager JE++. Exposure forecasting – ExpoCast – for data-poor chemicals in commerce and the environment. J Expo Sci Environ Epidemiol. 2022 Nov 8. doi: 10.1038/s41370-022-00492-z. Epub ahead of print. PMID: 36347934.
Johnson KJ, Auerbach SS, Stevens T, Barton-Maclaren TS, Costa E, Currie RA, Dalmas Wilk D, Haq S, Rager JE, Reardon AJF, Wehmas L, Williams A, O’Brien J, Yauk C, LaRocca JL, Pettit S. A Transformative Vision for an Omics-Based Regulatory Chemical Testing Paradigm. Toxicol Sci. 2022 Sep 27:kfac097. doi: 10.1093/toxsci/kfac097. Epub ahead of print. PMID: 36165699.
Freedman AN, Eaves LA, Rager JE, Gavino-Lopez N, Smeester L, Bangma J, Santos HP, Joseph RM, Kuban KC, O’Shea TM, Fry RC. The placenta epigenome-brain axis: placental epigenomic and transcriptomic responses that preprogram cognitive impairment. Epigenomics. 2022 Sep 8. doi: 10.2217/epi-2022-0061. Epub ahead of print. PMID: 36073148.
Carberry CK*, Koval LE*, Payton A#, Hartwell H, Ho Kim Y, Smith GJ, Reif DM, Jaspers I, Ian Gilmour M, Rager JE++. Wildfires and extracellular vesicles: Exosomal microRNAs as mediators of cross-tissue cardiopulmonary responses to biomass smoke. Environ Int. 2022 Sep;167:107419. doi: 10.1016/j.envint.2022.107419. Epub 2022 Jul 16. PMID: 35863239; PMCID: PMC9389917.
Chao A, Grossman J, Carberry C*, Lai Y, Williams AJ, Minucci JM, Thomas Purucker S, Szilagyi J, Lu K, Boggess K, Fry RC, Sobus JR, Rager JE++. Integrative exposomic, transcriptomic, epigenomic analyses of human placental samples links understudied chemicals to preeclampsia. Environ Int. 2022 Sep;167:107385. doi: 10.1016/j.envint.2022.107385. Epub 2022 Jun 30. PMID: 35952468.
Roell K, Koval LE*, Boyles R, Patlewicz G, Ring C, Rider CV, Ward-Caviness C, Reif DM, Jaspers I, Fry RC, Rager JE++. Development of the InTelligence And Machine LEarning (TAME) Toolkit for Introductory Data Science, Chemical-Biological Analyses, Predictive Modeling, and Database Mining for Environmental Health Research. Front Toxicol. 2022 Jun 22;4:893924. doi: 10.3389/ftox.2022.893924. PMID: 35812168; PMCID: PMC9257219.
Hickman E, Payton A#, Duffney P, Wells H, Ceppe AS, Brocke S, Bailey A, Rebuli ME, Robinette C, Ring B, Rager JE, Alexis NE, Jaspers I. Biomarkers of Airway Immune Homeostasis Differ Significantly with Generation of E-Cigarettes. Am J Respir Crit Care Med. 2022 Jun 22. doi: 10.1164/rccm.202202-0373OC. Epub ahead of print. PMID: 35731626.
Koval LE*, Dionisio KL, Friedman KP, Isaacs KK, Rager JE++. Environmental mixtures and breast cancer: identifying co-exposure patterns between understudied vs breast cancer-associated chemicals using chemical inventory informatics. J Expo Sci Environ Epidemiol. 2022 Jun 16. doi: 10.1038/s41370-022-00451-8. Epub ahead of print. PMID: 35710593.
Carberry CK*, Ferguson SS, Beltran AS, Fry RC, Rager JE++. Using liver models generated from human induced pluripotent stem cells (iPSCs) for evaluating chemical-induced modifications and disease across liver developmental stages. Toxicol In Vitro. 2022 Jun 7;83:105412. doi: 10.1016/j.tiv.2022.105412. Epub ahead of print. PMID: 35688329.
Avery CL, Howard AG, Ballou AF, Buchanan VL, Collins JM, Downie CG, Engel SM, Graff M, Highland HM, Lee MP, Lilly AG, Lu K, Rager JE, Staley BS, North KE, Gordon-Larsen P. Strengthening Causal Inference in Exposomics Research: Application of Genetic Data and Methods. Environ Health Perspect. 2022 May;130(5):55001. doi: 10.1289/EHP9098. Epub 2022 May 9. PMID: 35533073.
Payton A# , Perryman AN, Hoffman JR, Avula V, Wells H, Robinette C, Alexis NE, Jaspers I, Rager JE++, Rebuli ME. Cytokine signature clusters as a tool to compare changes associated with tobacco product use in upper and lower airway samples. Am J Physiol Lung Cell Mol Physiol. 2022 May 1;322(5):L722-L736. doi: 10.1152/ajplung.00299.2021. Epub 2022 Mar 23. PMID: 35318855; PMCID: PMC9054348.
Carberry CK*, Turla T*, Koval LE*, Hartwell H, Fry RC, Rager JE++. Chemical Mixtures in Household Environments: In Silico Predictions and In Vitro Testing of Potential Joint Action on PPARγ in Human Liver Cells. Toxics. 2022 Apr 19;10(5):199. doi: https://doi.org/10.3390/toxics10050199. PMID: 35622613.
Corton CJ, Mitchell CA, Auerbach S, Bushel JP, Ellinger-Ziegelbauer H, Escobar PA, Froetschl R, Harrill AH, Johnson K, Klaunig JE, Pandiri AR, Podtelezhnikov AA, Rager JE, Tanis KQ, van der Laan JW, Vespa A, Yauk CL, Pettit SD, Sistare FD. A Collaborative Initiative to Establish Genomic Biomarkers for Assessing Tumorigenic Potential to Reduce Reliance on Conventional Rodent Carcinogenicity Studies. Toxicol Sci. 2022 Jun 28;188(1):4-16. doi: 10.1093/toxsci/kfac041. PMID: 35404422; PMCID: PMC9238304.
Carberry CK*, Keshava D*, Payton A#, Smith GJ, Rager JE++. Approaches to Incorporate Extracellular Vesicles into Exposure Science, Toxicology, and Public Health Research. J Expo Sci Environ Epidemiol. 2022. Feb 25. doi: 10.1038/s41370-022-00417-w. Epub ahead of print. PMID: 35217808.
Eaves LA, Keil AP, Rager JE, George A, Fry RC. Analysis of the novel NCWELL database highlights two decades of co-occurrence of toxic metals in North Carolina private well water: Public health and environmental justice implications. Sci Total Environ. 2022 Mar 15;812:151479. doi: 10.1016/j.scitotenv.2021.151479. Epub 2021 Nov 9. PMID: 34767890.
Clark J, Eaves LA, Gaona AR, Santos HP, Smeester L, Bangma JT, Rager JE, O’Shea TM, Fry RC. Pre pregnancy BMI-associated miRNA and mRNA expression signatures in the placenta highlight a sexually dimorphic response to maternal underweight status. Sci Rep. 2021 Aug 3;11(1):15743. doi: 10.1038/s41598-021-95051-1. PMID: 34344912; PMCID: PMC8333418.
Manuck TA, Eaves LA, Rager JE, Sheffield-Abdullah K, Fry RC. Nitric oxide-related gene and microRNA expression in peripheral blood in pregnancy vary by self-reported race. Epigenetics. 2022 Jun-Jul;17(7):731-745. doi: 10.1080/15592294.2021.1957576. Epub 2021 Jul 24. PMID: 34308756; PMCID: PMC9336489.
2021
Clark J, Avula V, Ring C, Eaves LA, Howard T, Santos HP, Smeester L, Bangma JT, O’Shea TM, Fry RC, Rager JE++. Comparing the Predictivity of Human Placental Gene, microRNA, and CpG Methylation Signatures in Relation to Perinatal Outcomes. Toxicol Sci. 2021 Sep 28;183(2):269-284. PMID: 34255065; PMCID: PMC8478332.
Chang Y, Rager JE, Tilton SC. Linking Coregulated Gene Modules with Polycyclic Aromatic HydrocarbonRelated Cancer Risk in the 3D Human Bronchial Epithelium. Chem Res Toxicol. 2021 Jun 21;34(6):1445-1455. PMID: 34048650; PMCID: PMC8560124.
Manuck TA, Lai Y, Ru H, Glover AV, Rager JE, Fry RC, Lu K. Metabolites from mid-trimester plasma of pregnant patients at high-risk for preterm birth. Am J Obstet Gynecol MFM. 2021 Jul;3(4):100393. PMID: 33991707; PMCID: PMC8555706.
Manuck TA, Eaves LA, Rager JE, Fry RC. Mid-pregnancy maternal blood nitric oxide-related gene and miRNA expression are associated with preterm birth. Epigenomics. 2021 May;13(9):667-682. PMID: 33890487. PMCID: PMC8173522.
Ring C, Sipes NS, Hsieh JH, Carberry C*, Koval LE*, Klaren WD, Harris MA, Auerbach SS, Rager JE++. Predictive modeling of biological responses in the rat liver using in vitro Tox21 bioactivity: Benefits from highthroughput toxicokinetics. Comput Toxicol. 2021 May;18:100166. PMID: 34013136; PMCID: PMC8130852.
Rager JE, Clark J, Eaves LA, Avula V, Niehoff NM, Kim YH, Jaspers I, Gilmour MI. Mixtures modeling identifies chemical inducers versus repressors of toxicity associated with wildfire smoke. Sci Total Environ. 2021 Jun 25;775:145759. PMID: 33611182. PMCID: PMC8243846.
Mischler A, Karakis V, Mahinthakumar J, Carberry C*, San Miguel A, Rager J, Fry R, Rao B. Two distinct trophectoderm lineage stem cells from human pluripotent stem cells. J Biol Chem. Jan-Jun 2021;296:100386. PMID: 33556374. PMCID: PMC7948510.
2020
Jin B, Dunson DB, Rager JE, Reif DM, Engel SM, Herring AH. Bayesian Matrix Completion for Hypothesis Testing. statAP. 2020: arXiv:2009.08405v2.
Eaves LA, Nguyen HT, Rager JE, Sexton KG, Howard T, Smeester L, Freedman AN, Aagaard KM, Shope C, Lefer B, Flynn JH, Erickson MH, Fry RC, Vizuete W. Identifying the transcriptional response of cancer and inflammation-related genes in lung cells in relation to ambient air chemical mixtures. Environ Sci Technol. 2020 Nov 3;54(21):13807-13816. PMID: 33064461. PMCID: PMC7757424.
Eaves LA, Phookphan P, Rager JE, Bangma J, Santos HP, Smeester L, O’Shea TM, Fry RC. A role for microRNAs in the epigenetic control of sexually dimorphic gene expression in the human placenta. Epigenomics. 2020 Sep 9;12(17). PMID: PMID: 32901510. PMCID: PMC7607407.
Payton A*, Clark J, Eaves L, Santos HP, Smeester L, Bangma JT, O’Shea TM, Fry RC, Rager JE++. Placental Genomic and Epigenomic Signatures Associated with Infant Birth Weight Highlight Mechanisms Involved in Collagen and Growth Factor Signaling. Reprod Toxicol. 2020 Jul 25;96:221-230. PMID: 32721520. PMCID: PMC7855285.
Gomez JL, Chen A, Diaz MP, Zirn N, Gupta A, Britto C, Sauler M, Yan X, Stewart E, Santerian K, Grant N, Liu Q, Fry R, Rager J, Cohn L, Alexis N, Chupp GL. A Network of Sputum MicroRNAs is Associated with Neutrophilic Airway Inflammation in Asthma. Am J Respir Crit Care Med. 2020 Jul 1;202(1):51-64. PMID: PMCID: PMC7328332.
Zavala J, Freedman A, Jaspers I, Wambaugh JF, Higuchi M, Rager JE++. New Approach Methods to Evaluate Health Risks of Air Pollutants: Critical Design Criteria for In Vitro Exposure Testing. Int J Environ Res Public Health. 2020 Mar 23;17(6). PMID: 32210027. PMCID: PMC7143849.
Rager JE, Bangma J, Carberry C*, Chao A, Grossman J, Lu K, Manuck TA, Sobus JR, Szilagyi J, Fry RC. Review of the environmental prenatal exposome and its relationship to maternal and fetal health. Reprod Toxicol. 2020 Dec;98:1-12. PMID: 32061676. PMCID: PMC7442624.
2019
Rager JE, Carberry C*, Fry RC. Use of genome editing tools in environmental health research. Current Opinion in Toxicology. 2019 Dec;18:13-17. PMID: 31656878. PMCID: PMC6814161.
Chappell GA, Rager JE, Wolf J, Babic M, LeBlanc KJ, Ring CL, Harris MA, Thompson CM. Comparison of Gene Expression Responses in the Small Intestine of Mice Following Exposure to 3 Carcinogens Using the S1500+ Gene Set Informs a Potential Common Adverse Outcome Pathway. Toxicol Pathol. 2019 Oct; 47(7):851-PMID: 31558096. PMCID: PMC6827348.
Fry RC, Bangma J, Szilagyia J, Rager JE++. Developing novel in vitro methods for the risk assessment of developmental and placental toxicants in the environment. Toxicol Appl Pharmacol. 2019 Sep 1;378:114635.PMID: 31233757. PMCID: PMC6684208.
Wikoff D, Rager JE, Chappell GA, Fitch S, Haws L, Borghoff S. A framework for systematic evaluation and quantitative integration of mechanistic data in assessments of potential human carcinogens. Toxicol Sci. 2019 Feb 1;167(2):322-335. PMID: 30423162
Rager JE, Suh M, Chappell GA, Thompson CM, Proctor DM. Review of Transcriptomic Responses to Hexavalent Chromium Exposure in Lung Cells Supports a Role of Epigenetic Mediators in Carcinogenesis. Toxicol Lett. 2019 Jan 25. pii: S0378-4274(19)30012-8. PMID: 30690063.
Klaren WD, Ring C, Thompson CM, Borghoff S, Harris MA, Sipes NS, Hsieh J, Auerbach SS, Rager JE++. Identifying attributes that influence in vitro-to-in vivo concordance by comparing in vitro Tox21 bioactivity versus in vivo DrugMatrix transcriptomic responses across 130 chemicals. Toxicol Sci. 2019 Jan 1; 167(1):157-PMID: 30202884. PMCID: PMC6317427.
2018
Borghoff S, Fitch S, Rager JE, Huggett D. A hypothesis-driven weight-of-evidence analysis to evaluate potential endocrine activity of perfluorohexanoic acid. Regul Toxicol Pharmacol. 2018 Nov; 99:168-181. PMID: 30240830.
Wikoff DS, Thompson C, Rager J, Chappell G, Fitch S, Doepker C. Benefit-risk analysis for foods (BRAFO): Evaluation of exposure to dietary nitrates. Food and Chemical Toxicol. 2018 Oct; 120:709-723. PMID: 30134152.
Sobus JR, Wambaugh JF, Isaacs KK, Williams AJ, McEachran AD, Richard AM, Grulke CM, Ulrich EM, Rager JE, Strynar MJ, Newton SR. Integrating tools for non-targeted analysis research and chemical safety evaluations at the US EPA. J Expo Sci Environ Epidemiol. 2018 Sep;28(5):411-426. PMID: 29288256.
Suh M, Proctor D, Chappell G, Rager J, Thompson C, Borghoff S, Finch L, Ellis-Hutchings R, Wiench K. A review of the genotoxic, mutagenic, and carcinogenic potentials of several lower acrylates. Toxicology. 2018 Jun 1;402-403:50-67. PMID: 29689363. PMCID: PMC6661898.
Thompson CM, Kirman CR, Hays SM, Suh M, Harvey SE, Proctor DM, Rager JE, Haws LC, Harris MA. Integration of mechanistic and pharmacokinetic information to derive oral reference dose and margin-of-exposure values for hexavalent chromium. J Appl Toxicol. 2018 Mar; 38(3):351-365. PMID: 29064106. PMCID: PMC5813206.
2017
Rager JE, Auerbach SS, Chappell GA, Martin E, Thompson CM, Fry RC. Benchmark Dose Modeling Estimates of the Concentrations of Inorganic Arsenic That Induce Changes to the Neonatal Transcriptome, Proteome, and Epigenome in a Pregnancy Cohort. Chem Res Toxicol. 2017 Oct 16;30(10):1911-1920. PMID: 28927277.
Chappell GA, Rager JE++. Epigenetics in chemical-induced genotoxic carcinogenesis. Current Opinion in Toxicology. 2017 Oct;6:10-17.
Rager JE, Ring CL, Fry RC, Suh M, Proctor DM, Haws LC, Harris MA, Thompson CM. High-throughput screening data interpretation in the context of in vivo transcriptomic responses to oral Cr(VI) exposure. Toxicol Sci. 2017 Jul 1. 158(1):199-212. PMID: 28472532. PMCID: PMC5837509.
2016
Thompson CM, Rager JE, Suh M, Ring CL, Proctor DM, Haws LC, Fry RC, Harris MA. Transcriptomic Responses in the Oral Cavity of F344 Rats and B6C3F1 Mice Following Exposure to Cr(VI): Implications for Risk Assessment. Environ Mol Mutagen. 2016 Dec;57(9):706-716. PMID: 27859739. PMCID: PMC5215477.
Wikoff DS, Rager JE, Haws LC, Borghoff SJ. A high dose mode of action for Tetrabromobisphenol A-induced uterine adenocarcinomas in Wistar Han rats: a critical evaluation of key events in an adverse outcome pathway framework. Regul Toxicol Pharmacol. 2016 Jun;77:143-59. PMID: 26828025.
Thompson CM, Bichteler A, Rager JE, Suh M, Proctor DM, Haws LC, Harris MA. Comparison of in vivo genotoxic and carcinogenic potency to augment mode of action analysis: case study with hexavalent chromium. Mutat Res Genet Toxicol Environ Mutagen. 2016 Apr;800-801:28-34. PMID: 27085472.
Rager JE, Strynar MJ, Liang S, McMahen RL, Richard AM, Grulke CM, Wambaugh JF, Isaacs KK, Judson R, Williams AJ, Sobus JR. Linking high resolution mass spectrometry data with exposure and toxicity forecasts to advance high-throughput environmental monitoring. Environ Int. 2016 Mar;88:269-80. PMID: 26812473.
2015
Cook KD, Shpargel KB, Starmer J, Whitfield-Larry F, Conley B, Allard DE, Rager JE, Fry RC, Davenport ML, Magnuson T, Whitmire JK, Su MA. T Follicular Helper Cell-Dependent Clearance of a Persistent Virus Infection Requires T Cell Expression of the Histone Demethylase UTX. Immunity. 2015 Oct 20;43(4):703-14. PMID: PMCID: PMC4731234.
Rager JE, Tilley SK, Tulenko SE, Smeester L, Ray PD, Yosim A, Currier JM, Ishida MC, González-Horta Mdel C, Sánchez-Ramírez B, Ballinas-Casarrubias L, Gutiérrez-Torres DS, Drobná Z, Del Razo LM, García-Vargas GG, Kim WY, Zhou YH, Wright FA, Stýblo M, Fry RC. Identification of novel gene targets and putative regulators of arsenic-associated DNA methylation in human urothelial cells and bladder cancer. Chem Res Toxicol. 2015 Jun 15;28(6):1144-55. PMID: 26039340. PMCID: PMC4748849.
Martin E, González-Horta C, Rager J, Bailey KA, Sánchez-Ramírez B, Ballinas-Casarrubias L, Ishida MC, Gutiérrez-Torres DS, Hernández Cerón R, Viniegra Morales D, Baeza Terrazas FA, Saunders RJ, Drobná Z, Mendez MA, Buse JB, Loomis D, Jia W, García-Vargas GG, Del Razo LM, Stýblo M, Fry R. Metabolomic characteristics of arsenic-associated diabetes in a prospective cohort in Chihuahua, Mexico. Toxicol Sci. 2015 Apr;144(2):338-46. PMID: 25577196. PMCID: PMC4372663.
Rojas D, Rager JE, Smeester L, Bailey KA, Drobná Z, Rubio-Andrade M, Stýblo M, García-Vargas G, Fry RC. Prenatal arsenic exposure and the epigenome: Identifying sites of 5-methyl cytosine alterations that predict functional changes in gene expression in newborn cord blood and subsequent birth outcomes. Toxicol Sci. 2015 Jan;143(1):97-106. PMID: 25304211. PMCID: PMC4274382.
2014
Rager JE, Yosim A, Fry RC. Prenatal exposure to arsenic and cadmium impacts infectious disease-related genes within the glucocorticoid receptor signal transduction pathway. Int J Mol Sci. 2014 Dec 3;15(12):22374-91. PMID: 25479081. PMCID: PMC4284714.
Fry RC, Rager JE, Bauer RN, Sebastian E, Peden DB, Jaspers I, Alexis NE. Air toxics and epigenetic effects: Ozone altered microRNAs in the sputum of human subjects. Am J Physiol Lung Cell Mol Physiol. 2014 Jun 15;306(12):L1129-37. PMID: 24771714. PMCID: PMC4060009.
Bailey KA, Laine J, Rager JE, Sebastian E, Olshan A, Smeester L, Drobná Z, Styblo M, Rubio-Andrade M, García-Vargas G, Fry RC. Prenatal arsenic exposure and shifts in the newborn proteome: Interindividual differences in tumor necrosis factor (TNF)-responsive signaling. Toxicol Sci. 2014 Jun;139(2):328-37. PMID: PMCID: PMC4031624.
Rager JE, Bailey KA, Smeester L, Miller SK, Parker JS, Laine JE, Drobná Z, Currier J, Douillet C, Olshan AF, Rubio-Andrade M, Stýblo M, García-Vargas G, Fry RC. Prenatal arsenic exposure and the epigenome: Altered microRNAs associated with innate and adaptive immune signaling in newborn cord blood. Environ Mol Mutagen. 2014 Apr;55(3):196-208. PMID: 24327377. PMCID: PMC4023469.
Rager JE, Moeller BC, Miller SK, Kracko D, Doyle-Eisele M, Swenberg JA, Fry RC. Formaldehyde-associated changes in microRNAs: tissue and temporal specificity in the rat nose, white blood cells, and bone marrow. Toxicol Sci. 2014 Mar;138(1):36-46. PMID: 24304932. PMCID: PMC3930361.
Sanders AP, Smeester L, Rojas D, Debussycher T, Wu MC, Wright FA, Zhou YH, Laine JE, Rager JE, Swamy GK, Ashley-Koch A, Lynn Miranda M, Fry RC. Cadmium exposure and the epigenome: Exposure-associated patterns of DNA methylation in leukocytes from mother-baby pairs. Epigenetics. 2014 Feb 1;9(2):212-21. PMID: PMCID: PMC3962531.
2013
Rager JE, Bauer R, Muller LL, Smeester L, Carson JL, Brighton LE, Fry RC, Jaspers I. DNA methylation in nasal epithelial cells from smokers: identification of ULBP3-related effects. Am J Physiol Lung Cell Mol Physiol. 2013 Sep;305(6):L432-8. PMID: 23831618. PMCID: PMC3763036.
Rager JE, Moeller BC, Doyle-Eisele M, Kracko D, Swenberg JA, Fry RC. Formaldehyde and epigenetic alterations: microRNA changes in the nasal epithelium of nonhuman primates. Environ Health Perspect. 2013 Mar; 121(3):339-44. PMID: 23322811. PMCID: PMC3621188.
Ahir B, Sanders AP, Rager JE, Fry RC. Systems biology and birth defects prevention: blockade of the glucocorticoid receptor prevents arsenic-induced birth defects. Environ Health Perspect. 2013 Mar;121(3):332-8. PMID: 23458687. PMCID: PMC3616967.
Swenberg JA, Moeller BC, Lu K, Rager JE, Fry RC, Starr TB. Formaldehyde carcinogenicity research: 30 years and counting for mode of action, epidemiology, and cancer risk assessment. Toxicol Pathol. 2013 Feb;41(2):181- PMID: 23160431. PMCID: PMC3893912.
Bailey KA, Wu MC, Ward WO, Smeester L, Rager JE, García-Vargas G, Del Razo LM, Drobná Z, Stýblo M, Fry RC. Arsenic and the epigenome: Interindividual differences in arsenic metabolism related to distinct patterns of DNA methylation. J Biochem Mol Toxicol. 2013 Feb;27(2):106-15. PMID: 23315758. PMCID: PMC3892431.
2012
Tsang V, Fry RC, Niculescu MD, Rager JE, Saunders J, Paul DS, Zeisel SH, Waalkes MP, Stýblo M, Drobná Z. The epigenetic effects of a high prenatal folate intake in male mouse fetuses exposed in utero to arsenic. Toxicol Appl Pharmacol. 2012 Nov 1;264(3):439-50. PMID: 22959928. PMCID: PMC3478409.
Bauer RN, Brighton LE, Mueller L, Xiang Z, Rager JE, Fry RC, Peden DB, Jaspers I. Influenza enhances caspase-1 in bronchial epithelial cells from asthmatic volunteers and is associated with pathogenesis. J Allergy Clin Immunol. 2012 Oct;130(4):958-967.e14. PMID: 23021143. PMCID: PMC3470476.
Fry RC, Rager JE, Zhou H, Zou B, Brickey JW, Ting J, Lay JC, Peden DB, Alexis NE. Individuals with increased inflammatory response to ozone demonstrate muted signaling of immune cell trafficking pathways. Respir Res. 2012 Oct 3;13(1):89. PMID: 23033980. PMCID: PMC3607990.
Rager JE, Fry RC. The aryl hydrocarbon receptor pathway: a key component of the microRNA-mediated AML signalisome. Int. J. Environ. Res. Public Health. 2012 May;9:1939-53. PMID: 22754483. PMCID: PMC3386597.
Hernandez M, Brickey WJ, Alexis NE, Fry RC, Rager JE, Zhou B, Ting JP, Zhou H, Peden DB. Airway cells from atopic asthmatic patients exposed to ozone display an enhanced innate immune gene profile. J Allergy Clin Immunol. 2012 Jan;129(1):259-61.e1-2. PMID: 22196529. PMCID: PMC3254026.
2011
Rager JE, Lichtveld K, Ebersviller S, Smeester L, Jaspers I, Sexton KG, Fry RC. A toxicogenomic comparison of primary and photochemically altered air pollutant mixtures. Environ Health Perspect. 2011 Nov;119(11):1583-PMID: 21757418. PMCID: PMC3226493.
Sheh A, Ge Z, Parry NM, Muthupalani S, Rager JE, Raczynski AR, Mobley MW, McCabe AF, Fry RC, Wang TC, Fox JG. 17β-estradiol and tamoxifen prevent gastric cancer by modulating leukocyte recruitment and oncogenic pathways in Helicobacter pylori-infected INS-GAS male mice. Cancer Prev Res (Phila). 2011 Sep;4(9):1426-35. PMID: 21680705. PMCID: PMC3168115.
Benton MA, Rager JE, Smeester L, Fry RC. Comparative genomic analyses identify common molecular pathways modulated upon exposure to low doses of arsenic and cadmium. BMC Genomics. 2011 Apr 1;12:173. PMID: 21457566. PMCID: PMC3082247.
Rager JE, Smeester L, Jaspers I, Sexton KG, Fry RC. Epigenetic changes induced by air toxics: formaldehyde exposure alters miRNA expression profiles in human lung cells. Environ Health Perspect. 2011 Apr;119(4):494-PMID: 23322811. PMCID: PMC3080931.
Smeester L, Rager JE, Bailey KA, Guan X, Smith N, García-Vargas G, Del Razo LM, Drobná Z, Kelkar H, Stýblo M, Fry RC. Epigenetic changes in individuals with arsenicosis. Chem Res Toxicol. 2011 Feb 18;24(2):165-PMID: 21291286. PMCID: PMC3042796.