We studied nuclear foci formed by the C. elegans orthologs of the Protection of Telomeres 1 (Pot1) telomere binding protein, POT-1 and POT-2 (Fig. 1). C. elegans telomeric foci normally vanish in 1 cell embryos, but mutation of pot-1 and pot-2 telomere binding proteins results in gametes that alter the expression pattern of Pot1 foci for up to 6 generations. This reveals a novel and highly persistent form of transgenerational epigenetic inheritance. Evolutionary biologists Charles Darwin and Jean-Baptiste Lamarck predicted that it might be useful for parents to respond to certain environmental stresses by altering their germ cells in a manner that promotes fitness for multiple generations. We are curious about if and how altered levels of telomeric foci affect organismal fitness. This topic could be relevant to your children, grandchildren or great-grandchildren.