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Associated with Work at UNC-Chapel Hill

  1. Parker CL, Jacobs TM, Harit D, Lai SK§. (2019) Efficient and highly specific gene transfer using mutated lentiviral vectors redirected wih bispecific antibodies. mBio.  Submitted.
  2. Parker CL, McSweeney MD, Lucas AT, Jacobs TM, Wadsworth D, Zamboni WC, Lai SK§. (2019) Pretargeted delivery of PEG-coated drug carriers to breast tumors using multivalent, bispecific antibody against polyethylene glycol and HER2. Nanomedicine.  Submitted.
  3. Xu F, Jay M, Schiller JL, Schroeder HA, Wessler T, Chen A, Forest MG‡, Lai SK‡. (2019) Modeling barrier properties of intestinal mucus reinforced with IgG and secretory IgA against motile bacteria. ACS Infectious Disease.  Accepted.
  4. Hoang T, Toler E, DeLong K, Mafunda N, Bloom S, Sierden H, Moench T, Coleman JS, Hanes J, Kwon D, Lai SK, Cone R, Ensign LM. (2019) Polymicrobial and poorly acidifying vaginal microbiota degrade cervicovaginal mucus barrier to HIV-1. PLoS Pathogens.  Submitted.
  5. Patel KB, Mao ST, Forest MG, Lai SK, Newby JM. (2019) Limited processivity of single motors improves overall transport flux of self-assembled motor-cargo complexes. Physical Review E.  Accepted.
  6. Edwards VL*, Smith SB*, McComb EJ, Tamarelle J, Ma B, Humphrys MS, Gajer P, Gwilliam K, Schaefer AM, Lai SK, Mark KS, Brotman RM, Bavoil P, Forney LJ, Ravel J. (2019) Cervicovaginal microbiota-host interaction modulates Chlamydia trachomatis infection. mBio. Submitted.
  7. Schroeder HA, Newby J, Schaefer A, Subramani B, Tubbs A, Forest MG, Miao E, Lai SK§. (2019) LPS-binding IgG arrests actively motile Salmonella Typhimurium in gastrointestinal mucus.  Mucosal Immunology.  Resubmitted.
  8. McSweeney MD*, Price LSL*, Wessler T, Ciociola EC, Herity LB, Piscitelli JA, DeWalle AC, Harris TN, Chan A, Saw RS, Hu P, Jennette JC, Forest MG, Cao Y, Montgomery SA, Zamboni WC‡, Lai SK‡. (2019)  Overcoming anti-PEG antibody mediated accelerated blood clearance of PEGylated therapeutics by preinfusion with high molecular weight free PEG.  Journal of Controlled Release. Submitted.
  9. Schiller JL, Marvin A, McCallen JD, Lai SK§. (2019)  Robust antigen-specific tuning of the nanoscale barrier properties of biogels using matrix-associating IgG and IgM antibodies.  Acta Biomaterialia. 89:95-103, PMID: 30878451, [Impact 7.4]
  10. Jensen MA, Wang YY, Lai SK, Forest MG, McKinley SA. (2018) Antibody-mediated immobilization of virions in mucus.  Bulletin of Mathematical Biology. 1-27, [Impact 1.8] doi: https://doi.org/10.1101/500538, https://www.biorxiv.org/content/10.1101/500538v2
  11. McSweeney MD*, Wessler T*, Price LSL, Ciociola EC, Herity LB, Piscitelli JA, Zamboni WC, Forest MG, Cao Y‡, Lai SK‡. (2018) A minimal physiologically based pharmacokinetic model that predicts anti-PEG antibody-mediated clearance of PEGylated drugs in human and mouse. Journal of Controlled Release. 284:171-178, PMID: 29879519 PMCID: PMC6087483   [Impact 7.8]
  12. Huckaby J, Parker CL, Jacobs T, Schaefer A, Wadsworth D, Nguyen A, Newby J, Lai SK§. (2019) Engineering polymer-binding bispecific antibodies for enhanced pretargeted delivery of nanoparticles to mucus-covered epithelium.  Angewandte Chemie. 58(17):5604-5608, PMID: 30811861  [Impact 12.1].
  13. Newby J, Schaefer AM, Lee P, Forest MG‡, Lai SK‡. (2018) Convolutional neural networks automate detection for tracking of submicron-scale particles in 2D and 3D. PNAS. 115(36): 9026-9031, PMID: 30135100, PMCID: PMC6130393 [Impact 9.7]
  14. This Week in Machine Learning & AI Podcast (https://twimlai.com/talk/179; 200k listens/mo); WRAL TechWire “UNC-CH launches new company to commercialize particle tracking tech”; ScienceDaily “Better particle tracking software using artificial intelligence”; Phys.org
  15. Schroeder HA, Nunn KL, Schaefer A, Henry CE, Lam F, Pauly MH, Whaley KJ, Zeitlin L, Humphrys MS, Ravel J, Lai SK§. (2018) Herpes simplex virus binding IgG traps HSV in human cervicovaginal mucus across the menstrual cycle and diverse vaginal microbial composition. Mucosal Immunology. 11:1477–1486, PMID: 29988116, PMCID: PMC6485947  [Impact 7.5]
  16. Yang B, Schaefer A, Wang YY, McCallen JD, Lee P, Newby J, Arora H, Kumar PA, Zeitlin L, Whaley KJ, McKinley SA, Fischer W, Harit D‡, Lai SK‡. (2018) ZMapp Reinforces the Airway Mucosal Barrier Against Ebola Virus. Journal of Infectious Disease. 218(6):901-910, PMID: 29688496  [Impact 5.2]
  17. Fix SM, Nyankima AG, McSweeney MD, Tsuruta JK, Lai SK, Dayton PA. (2017) Accelerated clearance of ultrasound contrast agents containing polyethylene glycol (PEG) is associated with the generation of anti-PEG antibodies. Ultrasound in Medicine and Biology. 44(6):1266-1280. PMID: 29602540   [Impact 2.6]
  18. McSweeney MD, Versfeld ZC, Carpenter DM, Lai SK§. (2017) Physician awareness of immune responses to polyethylene glycol-drug conjugates. Clinical and Translational Science. 11(2):162-165. PMID: 29383836   [Impact 2.0]
  19. Newby J, Seim I, Lysy M, Ling Y, Huckaby J, Lai SK, Forest G. (2017) Technological strategies to estimate and control diffusive passage times through the airway mucus barrier in mucosal drug delivery. Adv Drug Deliv Rev. 124:64-81, PMID: 29246855 [Impact 15.6]
  20. Huckaby J, Lai SK§ (2017) PEGylation for enhancing nanoparticle diffusion in mucus. Adv Drug Deliv Rev. 124:125-139, PMID: 28882703 [Impact 15.6]
  21. Parker CL, Yang Q, Yang B, McCallen JD, Park SI‡, Lai SK‡ (2017) Multivalent interactions between streptavidin-based pretargeting fusion proteins and cell receptors impede efficient internalization of biotinylated nanoparticles. Acta Biomaterialia. 63:181-189, PMID: 28870833  [Impact 6.4] {Cited 2}
  22. McCallen J*, Prybylski J*, Yang Q, Lai SK§. (2017) Cross-reactivity of anti-PEG antibodies to other polymers containing C-C-O backbone. ACS Biomaterials Science & Engineering. 3(8):1605–1615. [Impact 4.4] {Cited 3}
  23. Newby J*, Schiller J*, Wessler T, Edelstein J, Forest MG‡, Lai SK‡. (2017) A blueprint for robust crosslinking of mobile species in biogels using third-party molecular anchors with short-lived anchor-matrix bonds. Nature Communications. 8(1):833, PMID: 29018239 PMCID: PMC5635012,  [Impact 12.4] {Cited 7}
  24. Yang Q, Parker CL, Lin Y, Press OW, Park SI‡, Lai SK‡. (2017) Pretargeting with bispecific fusion proteins facilitates delivery of nanoparticles to tumor cells with distinct surface antigens. J Controlled Release 255:73-80.  PMID: 28363519  [Impact 7.9] {Cited 4}
  25. Wang YY*, Harit D*, Subramani DB, Arora H, Kumar P, Lai SK§. (2017) Influenza-binding antibodies immobilise influenza viruses in fresh human airway mucus. European Respiratory Journal 49:1601709.  PMID: 28122865  [Impact 12.2] {Cited 9}
  26. McCallen JD*, Schaefer AM*, Lee P*, Hing L, Lai SK§. (2016) Stereolithography-based 3D printed “pillar plates” that minimizes fluid transfers during enzyme linked immunosorbent assays. Annals of Biomedical Engineering 45(4):982-989.  PMID: 27913951  [Impact 3.4] {Cited 2}
  27. Yang Q, Jacobs TM, McCallen JD, Moore DT, Huckaby JT, Edelstein JN, Lai SK§. (2016) Analysis of pre-existing IgG and IgM antibodies against polyethylene glycol (PEG) in the general population. Analytical Chemistry 88(23):11804-11812.  PMID: 27804292 DOI: 10.1021/acs.analchem.6b03437.  [Impact 6.0] {Cited 32)
  28. Lei M, Newby J, Lin C, Zhang L, Xu F, Kim W, Forest MG, Lai SK, Milowsky M, Wobker S, Huang L. (2016) The Binding Site Barrier Elicited by Tumor Associated Fibroblasts Interferes Disposition of Nanoparticles in Stroma-Vessel Type Tumors. ACS Nano 10(10): 9243–9258. PMID: 27666558   [Impact 13.7] {Cited 46}
  29. Henry C, Wang YY, Yang Q, Hoang T, Hoen T, Ensign L, Nunn KL, Schroeder H, McCallen J, Moench T, Cone R, Roffler S, Lai SK§. (2016) Anti-PEG antibodies alter the mobility and biodistribution of densely PEGylated nanoparticles in mucus. Acta Biomaterialia 43:61-70  PMID: 27424083, [Impact 6.4] {Cited 17}
  30. Wang YY, Schroeder H, Nunn KL, Woods K, Anderson DJ, Lai SK‡, Cone RA‡. (2016) Diffusion of Immunoglobulin G in shed vaginal epithelial cells and in cell-1 free regions of human cervicovaginal mucus. PLoS ONE. 11(6): e0158338. PMCID: PMC4928780.  [Impact 2.8] {Cited 10}
  31. Wessler T, Chen A, McKinley SA, Cone R, Forest MG‡, Lai SK‡. (2015) Using computational modeling to optimize the design of antibodies that trap viruses in mucus. ACS Infectious Disease. 2(1):82-92 PMCID: PMC4707974  [Impact 4.3] {Cited 14}
  32. Yang Q*, Parker C*, McCallen J, Lai SK§. (2015) Addressing challenges of heterogeneous tumor treatment using bispecific protein-mediated pretargeted drug delivery. J Controlled Release. 220(Pt B):715-26  PMCID: PMC4688191 [Impact 7.9]  {Cited 10}
  33. Wang YY, Nunn KL, McKinley S, Lai SK§. (2015) Minimizing biases associated with tracking analysis of submicron particles in heterogeneous biological fluids.  J Controlled Release.  220(Pt A):37-43.  PMCID: PMC4688199 [Impact 7.9]  {Cited 11}
  34. Nunn KL, Wang YY, Harit D, Humphrys M, Ma B, Cone R, Ravel J, Lai SK§. (2015) Enhanced trapping of HIV-1 by human cervicovaginal mucus is associated with Lactobacillus crispatus-dominant microbiota.  mBio. 6(5):e01084-1 PMCID: PMC4611035  [Impact: 6.8] {Cited 60}
  35. Highlighted in Witkin SS, Linhares IM. 2015. mBio 6(5):e01485-15.  mBiosphere: “Lactobacilli present in cervicovaginal mucus alter its protective properties”  Press Release by American Society for Microbiology, “Vaginal microbes influence whether mucus can trap HIV virus”.  Covered by numerous other media outlet, including International Business Times and Slate Magazine.
  36. Chen A, McKinley SA, Shi F, Wang S, Mucha PJ, Harit D, Forest MG, Lai SK§. (2015) Modeling of Virion Collisions in Cervicovaginal Mucus Reveals Limits on Agglutination as the Protective Mechanism of Secretory Immunoglobulin A. PLoS ONE. 10(7):e0131351  PMCID: PMC4488843   [Impact 3.2]  {Cited 6}
  37. Yang Q, Lai SK§. (2015) Emergence, characteristics and unaddressed questions about anti-PEG immunity. WIREs Nanomedicine & Nanobiotechnology (Invited Review).  7(5):655-77. PMCID: PMC4515207  [Impact 6.4]  {Cited 27}
  38. McKinley SA‡, Chen A, Shi F, Wang S, Mucha P, Forest MG, Lai SK‡. (2014) Modeling neutralization kinetics of HIV-1 by broadly neutralizing monoclonal antibodies in genital secretions coating the cervicovaginal mucosa. PLoS ONE. 9(6):e100598 PMCID: PMC4072659    [Impact 3.2]  {Cited 20}
  39. Chen A, McKinley SA, Shi F, Wang S, Mucha P, Forest MG‡, Lai SK‡. (2014) Transient antibody-mucin interactions produce a dynamic molecular shield against viral invasion. Biophysical Journal.  106(9):2028-2036. PMCID: PMC4017286  [Impact 3.5]  {Cited 28}
  40. Yang Q, Jones SW, Parker C, Zamboni WC, Jear JE, Lai SK§. (2014) Evading immune cell uptake and clearance requires PEG grafting at densities markedly exceeding the minimum for brush conformation. Molecular Pharmaceutics. 11(4):1250-8 PMID: 24521246  [Impact 4.6]  {Cited 109}
  41. Wang YY*, Kannan A*, Nunn KL, Murphy M, Subramani DB, Moench TM, Cone RA, Lai SK§. (2014) IgG in cervicovaginal mucus traps HSV and prevents vaginal Herpes infections. Mucosal Immunology. 7(5):1036-44 PMCID: PMC4122653  [Impact 7.4]  {Cited 49}