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Associated with Work at Johns Hopkins University and Cornell University

  1. Yu T, Chisholm J, Choi WJ, Anonuevo A, Pulicare S, Zhong W, Chen M, Fridley C, Lai SK, Ensign LM, Suk JS, Hanes J. (2016) Mucus‐Penetrating Nanosuspensions for Enhanced Delivery of Poorly Soluble Drugs to Mucosal Surfaces. Advanced Healthcare Materials. 5(21):2745-2750  PMID: 27717163  [Impact 5.6] {Cited 7}
  1. Ensign LM, Lai SK, Wang YY, Yang M, Mert O, Hanes J, Cone R. (2014) Pretreatment of Human Cervicovaginal Mucus with Pluronic F127 Enhances Nanoparticle Penetration without Compromising Mucus Barrier Properties to Herpes Simplex Virus. Biomacromolecules. 15(12):4403-9 PMCID: PMC4261994 [Impact 5.7]  {Cited 16}
  1. Yang M*, Lai SK*, Yu T*, Wang YY, Happe C, Zhong W, Zhang M, Anonuevo A, Fridley C, Hung A, Fu J, Hanes J. (2014) Nanoparticle penetration of human cervicovaginal mucus: The effect of polyvinyl alcohol. J Control Release. 192:202-8.  PMCID: PMC4194208  [Impact 7.9]  {Cited 62}
  1. Yang M, Yu T, Wood J, Wang YY, Tang BC, Zeng Q, Simons BW, Fu J, Chuang CM, Lai SK, Wu TC, Hung CF, Hanes J. (2014) Intraperitoneal delivery of paclitaxel by poly(ether-anhydride) microspheres effectively suppresses tumor growth in a murine metastatic ovarian cancer model. Drug Deliv Transl Res. 4(2):203-209. PMCID: PMC3956079. [Impact 3.4] {Cited 7}
  1. Suk JS, Kim AJ, Trehan K, Schneider CS, Cebotaru L, Woodward OM, Boylan NJ, Boyle MP, Lai SK, Guggino WB, Hanes J. (2014) Lung gene therapy with highly compacted DNA nanoparticles that overcome the mucus barrier. J Control Release. 178:8-17. PMCID: PMC3951606 [Impact 7.9]  {Cited 105}
  1. Yang M*, Yu T*, Wang YY, Lai SK, Zeng Q, Miao B, Tang BC, Simons BW, Ensign LM, Liu G, Chan KWY, Juang CY, Mert O, Wood J, Fu J, McMahon MT, Wu TC, Hung CF, Hanes J. (2014) Vaginal delivery of paclitaxel via nanoparticles with non-mucoadhesive surfaces suppresses cervical tumor growth. Advanced Healthcare Materials, 3(7):1044-52. PMCID: PMC4059793 [Impact 5.6] {Cited 59}
  1. Wang YY, Lai SK, Ensign LM, Zhong W, Cone R, Hanes J. (2013) The Microstructure and Bulk Rheology of Human Cervicovaginal Mucus Are Remarkably Resistant to Changes in pH. Biomacromolecules. 14(12):4429-35. PMCID: PMC3918948 [Impact 5.7]   {Cited 33}
  1. Yu T, Wang YY, Yang M, Zhong W, Pulicare S, Choi WJ, Mert O, Fu J, Lai SK, Hanes J. (2012) Biodegradable mucus-penetrating nanoparticles composed of diblock copolymers of polyethylene glycol and poly(lactic-co-glycolic acid). Drug Deliv. Transl. Res. 2 (2), 124-128. PMCID: PMC3818113  [Impact 3.4]   {Cited 51}
  1. Boylan NJ*, Kim AJ*, Suk JS, Adstamongkonkul P, Simons BW, Lai SK, Hanes J. (2012) Enhancement of Airway Gene Transfer by DNA Nanoparticles Using A pH-Responsive Block Copolymers of Polyethylene glycol and Poly-L-lysine. Biomaterials. 33:2361-2371 PMCID: PMC3259202 [Impact 8.8]  {Cited 42}
  1. Kim AJ, Boylan NJ, Suk JS, Lai SK, Hanes J. (2012) Non-degradative Intracellular Trafficking of Highly Compacted Polymeric DNA Nanoparticles. J Control Release. 158(1):102-7. PMCID: PMC3294172 [Impact 7.9]  {Cited 33}
  1. Boylan NJ, Suk JS, Lai SK, Jelinek R, Boyle MP, Cooper MJ, Hanes J. (2012) Highly compacted DNA nanoparticles with low MW PEG coatings: In vitro, ex vivo and in vivo evaluation. J Control Release. 157:72-79. PMCID: PMC3245330 [Impact 7.9]  {Cited 61}
  1. Mert O*, Lai SK*, Ensign L, Yang M, Wang YY, Wood J, Hanes J. (2011) A poly(ethylene glycol)-based surfactant for formulation of drug-loaded mucus penetrating particles. J Control Release. 157(3):455-60. PMCID: PMC3246104  [Impact 7.9]  {Cited 69}
  1. Suk JS, Boylan NJ, Trehan K, Tang BC, Schneider CS, Lin JM, Boyle MP, Zeitlin PL, Lai SK, Cooper MJ, Hanes J. (2011) N-acetylcysteine Enhances Cystic Fibrosis Sputum Penetration and Airway Gene Transfer by Highly Compacted DNA Nanoparticles. Molecular Therapy. 19(11): 1981–1989. PMCID: PMC3222526   [Impact 7.0]  {Cited 57}
  1. Jachak A, Lai SK, Suk JS, Biswal S, Breysse P, Hanes J. (2011) Transport of Metal Oxide Nanoparticles and Single-walled Carbon Nanotubes across Human Mucus. Nanotoxicology. 6(6):614-22. PMCID: PMC4696010 [Impact 5.8]  {Cited 36}
  1. Wang YY, Lai SK, So C, Schneider C, Cone R, Hanes J. (2011) Mucoadhesive nanoparticles may disrupt the protective human mucus barrier by altering its microstructure.. PLoS ONE. 6(6): e21547. PMCID: PMC3126822 [Impact 4.4]  {Cited 84}
  1. Lai SK, Suk JS, Pace A, Wang YY, Yang M, Mert O, Chen J, Kim J, Hanes J. (2011) Drug carrier nanoparticles that penetrate human chronic rhinosinusitis mucus. Biomaterials. 32(26): 6285-6290. PMCID: PMC3130096 [Impact 7.9]  {Cited 91}
  1. Hida K, Lai SK, Suk JS, Won SY, Boyle MP, Hanes J. (2011) Common gene therapy viral vectors do not efficiently penetrate sputum from cystic fibrosis patients. PLoS ONE. 6(5):e19919. PMCID: PMC3103503  [Impact 4.4]  {Cited 51}
  1. Yang M*,Lai SK*, Wang YY, Zhong W, Happe C, Zhang M, Fu J, Hanes J. (2011) Biodegradable Nanoparticles Composed Entirely of Safe Materials that Rapidly Penetrate Human Mucus. Angew Chem Int Ed Engl. 50(11):2597-600. PMCID: PMC3100893 [Impact 12.0]  {Cited 164}

Listed by Wiley-VCH in “Hot Topics:  Drug Delivery”; “Polymer coat helps nanoparticles penetrate mucus”, Royal Society of Chemistry.

  1. Suk JS, Lai SK, Boylan NJ, Dawson MR, Boyle MP, Hanes J. (2011) Rapid Transport of Muco-inert Nanoparticles in Cystic Fibrosis Sputum Treated with N-acetyl Cysteine. Nanomedicine (Lond). 6(2):365-75  PMCID: PMC3102009  [Impact 5.0]  {Cited 96}
  1. Lai SK, Wang YY, Hida K, Cone R, Hanes J. (2010) Nanoparticles reveal that human cervicovaginal mucus is riddled with pores larger than viruses. Proc Natl Acad Sci U S A. 107(2):598-603  PMCID: PMC2818964  [Impact 9.7]  {Cited 273}
    Selected for Faculty of 1000 Biology.
  1. Tang BT, Dawson M, Lai SK, Wang YY, Suk JS, Yang M, Zeitlin PL, Boyle MP, Fu J, Hanes J. (2009) Biodegradable polymer nanoparticles that rapidly penetrate the human mucus barrier. Proc Natl Acad Sci U S A. 106(46):19268-73. PMCID: PMC2780804 [Impact 9.7] {Cited 345}

In this issue, “Mucus is no match for coated nanoparticles”, PNAS; “Biodegradable Particles Can Bypass Mucus, Release Drugs Over Time”, Science Daily; selected for Faculty of 1000 Biology.

  1. Lai SK*, Hida K*, Shukair S, Wang YY, Cone R, Hope TJ, Hanes J. (2009) Human immunodeficiency virus type 1 is trapped by acidic but not by neutralized human cervicovaginal mucus. J Virology. 83:11196-11200.  PMCID: PMC2772788  [Impact 5.8]  {Cited 223}
  1. Suk JS*, Lai SK*, Wang YY, Boyle MP, Hanes J (2009). The Penetration of Fresh Undiluted Sputum Expectorated by Cystic Fibrosis Patients by Non-adhesive Polymer Nanoparticles. Biomaterials. 30(13):2591-2597. PMCID: PMC2661768    [Impact 8.8]  {Cited 224}
  1. Lai SK*, Wang YY*, Cone R, Wirtz D, Hanes J (2009). Altering mucus rheology to “solidify” human mucus at the nanoscale. PLoS ONE. 4(1): e4294. PMCID: PMC2627937  [Impact 4.4]  {Cited 115}
    “A Better Mesh: Researchers ‘Tighten’ Body’s Protective Coating”, Science Daily; featured in over 10 other science/medical news outlets.
  1. Lai SK‡, Wang YY, Hanes J‡. (2009) Mucus-penetrating nanoparticles for drug and gene delivery to mucosal tissues. Adv Drug Deliv Rev. 61(2):158-171. PMCID: PMC2667119   [Impact 15.6]  {Cited 1111}

Featured on the Cover

  1. Lai SK, Wang YY, Wirtz D, Hanes J. (2009) Micro- and macrorheology of mucus. Adv Drug Deliv Rev. 61(2):86-100. PMCID: PMC2736374  [Impact 15.6]  {Cited 620}
  1. Wang YY*, Lai SK*, Suk JS, Pace A, Cone R, Hanes J. (2008) Addressing the PEG Muco-adhesivity Paradox to Engineer Nanoparticles that “Slip” through the Human Mucus Barrier.
    Angew Chem Int Ed Engl. 47(50):9726-9729. PMCID: PMC2666733   [Impact 12.0] {Cited 384}

News & Views: “Drug delivery: Stealth particles give mucus the slip”, Nature Materials (2009) 8: 11 – 13; News Blog: “Breaking the mucus barrier”, The Scientist (2008); also featured in over 20 other science/medical news outlets.

  1. Lai SK, Hida K, Chen C, Hanes J. (2008) Characterization of the intracellular dynamics of a non-degradative pathway accessed by polymer nanoparticles. J Control Release. 125(2):107-111. PMCID: PMC2220013 [Impact 7.9]  {Cited 79}
  1. Lai SK, Hida K, Man ST, Chen C, Machamer C, Schroer TA, Hanes J. (2007) Privileged delivery of polymer nanoparticles to the perinuclear region of live cells via a non-clathrin, non-degradative pathway. Biomaterials. 28(18): 2876-2884. PMID: 17363053  [Impact 8.8]  {Cited 261}

Editor’s choice, Drug Discovery Today (2007).

  1. Lai SK, O’Hanlon ED, Harrold S, Man ST, Wang YY, Cone R, Hanes J. (2007) Rapid transport of large polymeric nanoparticles in fresh undiluted human mucus. Proc Natl Acad Sci U S A. 104(5):1482-1487. PMCID: PMC1785284  [Impact 9.7] {Cited 778}
    Research highlights include: “Nanoparticles: Against the flow”, Nature Nanotechnology (2007); “Nanoparticles and mucus”, Journal of American Medical Association (2007) 297(9):941; “Coated Nanoparticles Solve Sticky Drug-Delivery Problem”, National Cancer Institute, Alliance for Nanotechnology in Cancer Newsletter.
  1. Suk JS, Suh J, Lai SK, Hanes J. (2007) Quantifying the intracellular transport of viral and nonviral gene vectors in primary neurons. Exp Biol Med (Maywood). 232(3): 461-9. PMID: 17327481  [Impact 2.4]  {Cited 76}
    Society of Experimental Biology & Medicine Best Paper Award for 2007, Basic Biology Section.
  1. Castellanos M, Kushiro K, Lai SK, Shuler ML. (2007) A genomically/chemically complete module for synthesis of lipid membrane in a minimal cell. Biotechnol Bioeng. 97(2):397-409.  PMID: 17149771   [Impact 3.3]  {Cited 19}
  1. Suh J, Choy KL, Lai SK, Suk JS, Tang B, Prabhu S, Hanes J. (2007) PEGylation of nanoparticles improves their cytoplasmic transport. Int J Nanomedicine. 2(4):735-41. PMCID: PMC2676827. [Impact 5.0]  {Cited 129}
  1. Suk JS, Suh J, Choy K, Lai SK, Fu J, and Hanes J. (2006) Gene delivery to differentiated neurotypic cells with RGD and HIV Tat peptide functionalized polymeric nanoparticles. Biomaterials. 27(29):5143-5150.  PMID: 16769110  [Impact 8.8]  {Cited 155}
    Listed in 2006 by Science Direct as a “Top 25 Hottest Article” in the area of Biomaterials (based on times downloaded).
  2. Lai SK, Batra A, Cohen C. (2005) Characterization of polydimethylsiloxane elastomer degradation via cross-linker hydrolysis.  Polymer. 46: 4204-4211. [Impact 1.5]  {Cited 25}