2023
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McCall, J.R., DeRuiter, R., Ross, M., Santibanez, F., Hingtgen, S.D., Pinton, G.F., Dayton, P.A. 2023. Longitudinal 3-D Visualization of Microvascular Disruption and Perfusion Changes in Mice During the Evolution of Glioblastoma Using Super-Resolution Ultrasound. IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control.
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Woodell, A.S., Landoni, E., Valdivia, A., Buckley, A., Ogunnaike, E.A., Dotti, G., Hingtgen, S.D., 2023. Utilizing induced neural stem cell-based delivery of a cytokine cocktail to enhance chimeric antigen receptor-modified T-cell therapy for brain cancer. Bioengineering & Translational Medicine.
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Mann, B. et al., 2023. A living ex vivo platform for functional, personalized brain cancer diagnosis. Cell Reports Medicine.
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Nehama, D., Woodell, A.S., Maingi, S.M., Hingtgen, S.D., Dotti, G., 2023. Cell-based therapies for glioblastoma: Promising tools against tumor heterogeneity. Neuro-Oncology.
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Beltran-Huarac, J., Yamaleyeva, D.N., Dotti, G., Hingtgen, S., Sokolsky-Papkov, M., Kabanov, A.V., 2023. Magnetic Control of Protein Expression via Magneto-mechanical Actuation of ND-PEGylated Iron Oxide Nanocubes for Cell Therapy. ACS Applied Material Interfaces.
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Thang, M., Mellows, C., Mercer-Smith, A., Nguyen, P., Hingtgen, S., 2023. Current approaches in enhancing TRAIL therapies in glioblastoma. Neuro-Oncology Advances.
2022
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Satterlee, A.B., Dunn, D.E., Valdivia, A., Malawsky, D., Buckley, A., Gershon, T., Floyd, S. and Hingtgen, S., 2022. Spatiotemporal Analysis of Induced Neural Stem Cell Therapy to Overcome Advanced Glioblastoma Recurrence. Molecular Therapy-Oncolytics.
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Mercer-Smith, A.R., Buckley, A., Valdivia, A., Jiang, W., Thang, M., Bell, N., Kumar, R.J., Bomba, H.N., Woodell, A.S., Luo, J., Floyd, S.R., and Hingtgen, S.D., 2022. Next-generation Tumor-homing Induced Neural Stem Cells as an Adjuvant to Radiation for the Treatment of Metastatic Lung Cancer. Stem Cell Reviews and Reports, pp.1-20.
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Bomba, H.N., Carey‐Ewend, A., Sheets, K.T., Valdivia, A., Goetz, M., Findlay, I.A., Mercer‐Smith, A., Kass, L.E., Khagi, S. and Hingtgen, S.D., 2022. Use of FLOSEAL® as a scaffold and its impact on induced neural stem cell phenotype, persistence, and efficacy. Bioengineering & Translational Medicine, p.e10283.
2021
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Mercer-Smith, A.R., Findlay, I.A., Bomba, H.N. and Hingtgen, S.D., 2021. Intravenously Infused Stem Cells for Cancer Treatment. Stem Cell Reviews and Reports, 17(6), pp.2025-2041.
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Mercer-Smith, A.R., Jiang, W., Bago, J.R., Valdivia, A., Thang, M., Woodell, A.S., Montgomery, S.A., Sheets, K.T., Anders, C.K. and Hingtgen, S.D., 2021. Cytotoxic Engineered Induced Neural Stem Cells as an Intravenous Therapy for Primary Non–Small Cell Lung Cancer and Triple-Negative Breast Cancer. Molecular Cancer Therapeutics, 20(11), pp.2291-2301.
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Ogunnaike, E.A., Valdivia, A., Yazdimamaghani, M., Leon, E., Nandi, S., Hudson, H., Du, H., Khagi, S., Gu, Z., Savoldo, B., Ligler, F.S., Hingtgen, S., and Dotti, G., 2021. Fibrin gel enhances the antitumor effects of chimeric antigen receptor T cells in glioblastoma. Science advances, 7(41), p.eabg5841.
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Carey-Ewend, A.G., Hagler, S.B., Bomba, H.N., Goetz, M.J., Bago, J.R. and Hingtgen, S.D., 2021. Developing bioinspired three-dimensional models of brain cancer to evaluate tumor-homing neural stem cell therapy. Tissue Engineering Part A, 27(13-14), pp.857-866.
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Jiang, W., Yang, Y., Mercer-Smith, A.R., Valdivia, A., Bago, J.R., Woodell, A.S., Buckley, A.A., Marand, M.H., Qian, L., Anders, C.K. and Hingtgen, S.D., 2021. Development of next-generation tumor-homing induced neural stem cells to enhance treatment of metastatic cancers. Science Advances, 7(24), p.eabf1526.
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Bomba, H.N., Sheets, K.T., Valdivia, A., Khagi, S., Ruterbories, L., Mariani, C.L., Borst, L.B., Tokarz, D.A. and Hingtgen, S.D., 2021. Personalized‐induced neural stem cell therapy: Generation, transplant, and safety in a large animal model. Bioengineering & Translational Medicine, 6(1), p.e10171.
2020
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Gawley, M., Almond, L., Daniel, S., Lastakchi, S., Kaur, S., Detta, A., Cruickshank, G., Miller, R., Hingtgen, S., Sheets, K. and McConville, C., 2020. Development and in vivo evaluation of Irinotecan-loaded Drug Eluting Seeds (iDES) for the localised treatment of recurrent glioblastoma multiforme. Journal of Controlled Release, 324, pp.1-16.
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Graham-Gurysh, E.G., Murthy, A.B., Moore, K.M., Hingtgen, S.D., Bachelder, E.M. and Ainslie, K.M., 2020. Synergistic drug combinations for a precision medicine approach to interstitial glioblastoma therapy. Journal of Controlled Release, 323, pp.282-292.
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Buckley, A., Hagler, S.B., Lettry, V., Bagó, J.R., Maingi, S.M., Khagi, S., Ewend, M.G., Miller, C.R. and Hingtgen, S.D., 2020. Generation and profiling of tumor-homing induced neural stem cells from the skin of cancer patients. Molecular Therapy, 28(7), pp.1614-1627.
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Moore, K.M., Murthy, A.B., Graham-Gurysh, E.G., Hingtgen, S.D., Bachelder, E.M. and Ainslie, K.M., 2020. Polymeric biomaterial scaffolds for tumoricidal stem cell glioblastoma therapy. ACS Biomaterials Science & Engineering, 6(7), pp.3762-3777.
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Moore, K.M., Graham-Gurysh, E.G., Bomba, H.N., Murthy, A.B., Bachelder, E.M., Hingtgen, S.D., and Ainslie, K.M., 2020. Impact of composite scaffold degradation rate on neural stem cell persistence in the glioblastoma surgical resection cavity. Materials Science and Engineering: C, 111, p.110846.
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Sheets, K.T., Ewend, M.G., Mohiti-Asli, M., Tuin, S.A., Loboa, E.G., Aboody, K.S. and Hingtgen, S.D., 2020. Developing implantable scaffolds to enhance neural stem cell therapy for post-operative glioblastoma. Molecular Therapy, 28(4), pp.1056-1067.
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Graham-Gurysh, E.G., Moore, K.M., Schorzman, A.N., Lee, T., Zamboni, W.C., Hingtgen, S.D., Bachelder, E.M. and Ainslie, K.M., 2020. Tumor responsive and tunable polymeric platform for optimized delivery of paclitaxel to treat glioblastoma. ACS applied materials & interfaces, 12(17), pp.19345-19356.
2019
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Satterlee, A.B., Dunn, D.E., Lo, D.C., Khagi, S. and Hingtgen, S., 2019. Tumoricidal stem cell therapy enables killing in novel hybrid models of heterogeneous glioblastoma. Neuro-oncology, 21(12), pp.1552-1564.
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Suryaprakash, S., Lao, Y.H., Cho, H.Y., Li, M., Ji, H.Y., Shao, D., Hu, H., Quek, C.H., Huang, D., Mintz, R.L., Bagó, J.R., Hingtgen, S.D., Lee, K., and Leong, K.W., 2019. Engineered mesenchymal stem cell/nanomedicine spheroid as an active drug delivery platform for combinational glioblastoma therapy. Nano Letters, 19(3), pp.1701-1705.
2018
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Sheets, K.T., Bagó, J.R., Paulk, I.L. and Hingtgen, S.D., 2018. Image-guided resection of glioblastoma and intracranial implantation of therapeutic stem cell-seeded scaffolds. JoVE (Journal of Visualized Experiments), (137), p.e57452.
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Okolie, O., Irvin, D.M., Bago, J.R., Sheets, K., Satterlee, A., Carey-Ewend, A.G., Lettry, V., Dumitru, R., Elton, S., Ewend, M.G., Miller, C.R., and Hingtgen, S.D., 2018. Intra-cavity stem cell therapy inhibits tumor progression in a novel murine model of medulloblastoma surgical resection. PloS one, 13(7), p.e0198596.
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Graham-Gurysh, E., Moore, K.M., Satterlee, A.B., Sheets, K.T., Lin, F.C., Bachelder, E.M., Miller, C.R., Hingtgen, S.D., and Ainslie, K.M., 2018. Sustained delivery of doxorubicin via acetalated dextran scaffold prevents glioblastoma recurrence after surgical resection. Molecular pharmaceutics, 15(3), pp.1309-1318.
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Sheets, K.T., Bagó, J.R. and Hingtgen, S.D., 2018. Delivery of cytotoxic mesenchymal stem cells with biodegradable scaffolds for treatment of postoperative brain cancer. In Targeted drug delivery (pp. 49-58). Humana Press, New York, NY.
2017
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Lettry, V., Hagler, S.B., Khagi, S. and Hingtgen, S.D., 2017. Tumor-homing stem cell therapy for brain cancer. Current Surgery Reports, 5(10), pp.1-14.
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Bagó, J.R., Okolie, O., Dumitru, R., Ewend, M.G., Parker, J.S., Werff, R.V., Underhill, T.M., Schmid, R.S., Miller, C.R. and Hingtgen, S.D., 2017. Tumor-homing cytotoxic human induced neural stem cells for cancer therapy. Science translational medicine, 9(375), p.eaah6510.
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Featured on the cover of the journal, was the cover story for the NIH NCATS website, and featured in numerous other on-line and media outlets including “The Stem Cell Podcast”, Genetic Engineering & Biotechnology news, and the international TV show “Carte Blanche”.
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2016
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Okolie, O., Bago, J.R., Schmid, R.S., Irvin, D.M., Bash, R.E., Miller, C.R. and Hingtgen, S.D., 2016. Reactive astrocytes potentiate tumor aggressiveness in a murine glioma resection and recurrence model. Neuro-oncology, 18(12), pp.1622-1633.
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Bagó, J.R., Pegna, G.J., Okolie, O., Mohiti-Asli, M., Loboa, E.G. and Hingtgen, S.D., 2016. Electrospun nanofibrous scaffolds increase the efficacy of stem cell-mediated therapy of surgically resected glioblastoma. Biomaterials, 90, pp.116-125.
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Bagó, J.R., Sheets, K.T. and Hingtgen, S.D., 2016. Neural stem cell therapy for cancer. Methods, 99, pp.37-43.
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Bagó, J.R., Pegna, G.J., Okolie, O. and Hingtgen, S.D., 2016. Fibrin matrices enhance the transplant and efficacy of cytotoxic stem cell therapy for post-surgical cancer. Biomaterials, 84, pp.42-53.
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Kim, M.S., Haney, M.J., Zhao, Y., Mahajan, V., Deygen, I., Klyachko, N.L., Inskoe, E., Piroyan, A., Sokolsky, M., Okolie, O., Hingtgen, S.D., Kabanov, A.V., and Batrakova, E.V., 2016. Development of exosome-encapsulated paclitaxel to overcome MDR in cancer cells. Nanomedicine: Nanotechnology, Biology and Medicine, 12(3), pp.655-664.
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Bagó, J.R., Alfonso-Pecchio, A., Okolie, O., Dumitru, R., Rinkenbaugh, A., Baldwin, A.S., Miller, C.R., Magness, S.T. and Hingtgen, S.D., 2016. Therapeutically engineered induced neural stem cells are tumour-homing and inhibit progression of glioblastoma. Nature communications, 7(1), pp.1-13.
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Featured in “The News Observer”, WRAL nightly news, WNCN news, “Radio In Vivo” talk show, and in numerous other media outlets.
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2015
2014
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Klyachko, N.L., Haney, M.J., Zhao, Y., Manickam, D.S., Mahajan, V., Suresh, P., Hingtgen, S.D., Mosley, R.L., Gendelman, H.E., Kabanov, A.V. and Batrakova, E.V., 2014. Macrophages offer a paradigm switch for CNS delivery of therapeutic proteins. Nanomedicine, 9(9), pp.1403-1422.
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Duebgen, M., Martinez-Quintanilla, J., Tamura, K., Hingtgen, S., Redjal, N., Wakimoto, H. and Shah, K., 2014. Stem cells loaded with multimechanistic oncolytic herpes simplex virus variants for brain tumor therapy. JNCI: Journal of the National Cancer Institute, 106(6).
2013
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Hingtgen, S., 2013. Multifunctional Molecules for Interrogating Stem Cell‐Based Therapeutics. Stem Cell Therapeutics for Cancer, pp.257-271.
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Haney, M.J., Zhao, Y., Harrison, E.B., Mahajan, V., Ahmed, S., He, Z., Suresh, P., Hingtgen, S.D., Klyachko, N.L., Mosley, R.L. and Gendelman, H.E., 2013. Specific transfection of inflamed brain by macrophages: a new therapeutic strategy for neurodegenerative diseases. PloS one, 8(4), p.e61852.
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Hingtgen, S., Figueiredo, J.L., Farrar, C., Duebgen, M., Martinez-Quintanilla, J., Bhere, D. and Shah, K., 2013. Real-time multi-modality imaging of glioblastoma tumor resection and recurrence. Journal of neuro-oncology, 111(2), pp.153-161.
2012 and earlier
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Hingtgen, S., Kasmieh, R., Elbayly, E., Nesterenko, I., Figueiredo, J.L., Dash, R., Sarkar, D., Hall, D., Kozakov, D., Vajda, S. and Fisher, P.B., 2012. A first-generation multi-functional cytokine for simultaneous optical tracking and tumor therapy. PloS one, 7(7), p.e40234.
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Kauer, T.M., Figueiredo, J.L., Hingtgen, S. and Shah, K., 2012. Encapsulated therapeutic stem cells implanted in the tumor resection cavity induce cell death in gliomas. Nature neuroscience, 15(2), pp.197-204.
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Hingtgen, S.D., Li, Z., Kutschke, W., Tian, X., Sharma, R.V. and Davisson, R.L., 2010. Superoxide scavenging and Akt inhibition in myocardium ameliorate pressure overload-induced NF-κB activation and cardiac hypertrophy. Physiological Genomics, 41(2), pp.127-136.
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Hingtgen, S.D., Kasmieh, R., van de Water, J., Weissleder, R. and Shah, K., 2010. A novel molecule integrating therapeutic and diagnostic activities reveals multiple aspects of stem cell-based therapy. Stem Cells, 28(4), pp.832-841.
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Sasportas, L.S., Kasmieh, R., Wakimoto, H., Hingtgen, S., van de Water, J.A., Mohapatra, G., Figueiredo, J.L., Martuza, R.L., Weissleder, R. and Shah, K., 2009. Assessment of therapeutic efficacy and fate of engineered human mesenchymal stem cells for cancer therapy. Proceedings of the national academy of sciences, 106(12), pp.4822-4827.
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Hingtgen, S., Ren, X., Terwilliger, E., Classon, M., Weissleder, R. and Shah, K., 2008. Targeting multiple pathways in gliomas with stem cell and viral delivered S-TRAIL and Temozolomide. Molecular cancer therapeutics, 7(11), pp.3575-3585.
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Shah, K., Hingtgen, S., Kasmieh, R., Figueiredo, J.L., Garcia-Garcia, E., Martinez-Serrano, A., Breakefield, X. and Weissleder, R., 2008. Bimodal viral vectors and in vivo imaging reveal the fate of human neural stem cells in experimental glioma model. Journal of Neuroscience, 28(17), pp.4406-4413.
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Arwert, E., Hingtgen, S., Figueiredo, J.L., Bergquist, H., Mahmood, U., Weissleder, R. and Shah, K., 2007. Visualizing the dynamics of EGFR activity and antiglioma therapies in vivo. Cancer research, 67(15), pp.7335-7342.
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Hingtgen, S.D., Tian, X., Yang, J., Dunlay, S.M., Peek, A.S., Wu, Y., Sharma, R.V., Engelhardt, J.F. and Davisson, R.L., 2006. Nox2-containing NADPH oxidase and Akt activation play a key role in angiotensin II-induced cardiomyocyte hypertrophy. Physiological genomics, 26(3), pp.180-191