Optimizing the delivery of cell therapies using biomaterial matrices
The implantation of therapeutic cells into a harsh post-surgical site can significantly limit the ability for the cells to perform their intended function. However, implantation of cellular therapeutics at the time of surgery is often the most convenient in the context of clinical workflow. Thus, improving the survival and retention of cells at the implantation site is crucial for ensuring therapeutic durability and efficacy.
Our lab develops and characterizes the ability of commercially-available and custom-engineered biomaterials to protect our therapeutic neural stem cells for post-surgical glioblastoma treatment. We analyze the ability of these materials to protect our stem cells in the glioblastoma resection cavity – without hindering their therapeutic function – in our novel mouse models of glioblastoma resection.
Relevant publications:
Bomba, H.N., Carey-Ewend, A., Sheets, K.T., Valdivia, A., Goetz, M., Findlay, I.A., Mercer-Smith, A., Kass, L.E., Khagi, S. and Hingtgen, S.D., 2022. Use of FLOSEAL® as a scaffold and its impact on induced neural stem cell phenotype, persistence, and efficacy. Bioengineering & Translational Medicine, p.e10283.
Sheets, K.T., Ewend, M.G., Mohiti-Asli, M., Tuin, S.A., Loboa, E.G., Aboody, K.S. and Hingtgen, S.D., 2020. Developing implantable scaffolds to enhance neural stem cell therapy for post-operative glioblastoma. Molecular Therapy, 28(4), pp.1056-1067.
